CBD Oil for anxiety and more
06-02-2019, 04:09 AM,
#21
RE: CBD Oil for anxiety and more
I'm allergic to cannabis (THC)... but from reading this thread; wondering if CBD oil could help me & wanting to understand more about interactions with other medicines I found this (amongst numerous articles)

interesting info:

https://cbdoilreview.org/cbd-cannabidiol/cbd-p-450-enzyme/

(NB: it's a pro- CBD site - but has list of interactions, also other recommendations, info etc)

Quote:"Cannabidiol can inhibit the cytochrome P450 system’s ability to metabolize certain drugs, leading to an overall increase in processing times.

Interestingly, CBD oil is not alone in its effect on drug metabolism. Grapefruit, watercress, St. John’s Wort, and goldenseal all have a similar impact in terms of CYP450 inhibition.

When the CYP450 system is impacted in this way, it leads to higher levels of certain drugs in your system at one time. This can cause unwanted side effects, and sometimes, an overdose.

If you are taking a medication affected by cannabidiol, you should consult your doctor to make sure that it is safe for you to supplement your personal care routine with CBD oil. From there, the two of you may consider adjusting the dosage on your medications so that you can use both products safely.  
Drugs that Interact with Cannabidiol

Any drug metabolized by CYP450 enzymes could potentially interact with cannabidiol. According to the Indiana University Department of Medicine, drugs known to use the CYP450 system include:

   Steroids
   HMG CoA reductase inhibitors
   Calcium channel blockers
   Antihistamines
   Prokinetics
   HIV antivirals
   Immune modulators
   Benzodiazepines
   Antiarrythmics
   Antibiotics
   Anesthetics
   Antipsychotics
   Antidepressants
   Anti-epileptics
   Beta blockers
   PPIs
   NSAIDs
   Angiotension II blockers
   Oral hypoglycemic agents
   Sulfonylureas

This list does not include all of the potential medications impacted by cannabidiol. Nor will every medication in the categories contained on this list will cause an interaction. For these reasons, you should consult with a medical professional before supplementing with CBD oil.

There are certain medications, known as “prodrugs,” that need to be metabolized to produce the therapeutic compound. In other words, you ingest an inactive compound and once in the body, it is processed into the active drug. If this processing is dependent on CYP3A4 (part of the larger CYP450 system), then inhibitors can result in too little active drug in the body for the desired therapeutic effect.

Codeine, for example, is a prodrug that is metabolized into morphine which provides the effect.

Vyvanse and Concerta are two other popular pharmaceutical medications for ADHD that fall into this category.

If you are worried that your CYP450 pathway may not be functioning properly, physicians can test the system to ensure that the medications you take are metabolizing as expected."

nb: if you scroll past this info there are other sections
- Combining Alcohol and CBD Oil
- Caffeine and CBD
- Addictive?
- How To Use CBD Oil

and the 'reply' section at the bottom has some potentially useful info too
for example:

Quote:"never take CBD with any blood thinning medication with out consulting your doctor first"

I hope this is helpful additional info - I'm not sure where I'm at with whether it could be right for me - but knowing the potential interactions it has (or other drugs can have with it) - looks to be important.

Depending on your usage of other medications/supplements/herbs - finding doctors who have good knowledge to advise either about a holistic usage/transfer plan/taper plan (from pharma drugs to - and/or in conjunction with cbd) would be sensible.

oooh... this is for Australia - https://cannabiscompany.com.au/blogs/news/cbd-use-benefits

oh... it's prescription only in Aus

https://cannabiscompany.com.au/blogs/news/how-to-access-cbd-medical-cannabis-in-australia
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Messages In This Thread
RE: CBD Oil for anxiety and more - Merrick - 05-16-2019, 03:40 AM
RE: CBD Oil for anxiety and more - Merrick - 05-16-2019, 04:45 AM
RE: CBD Oil for anxiety and more - Jade - 05-16-2019, 11:41 AM
RE: CBD Oil for anxiety and more - Glow - 05-16-2019, 01:58 PM
RE: CBD Oil for anxiety and more - Glow - 05-16-2019, 02:05 PM
RE: CBD Oil for anxiety and more - Merrick - 05-16-2019, 02:08 PM
RE: CBD Oil for anxiety and more - Glow - 05-16-2019, 02:24 PM
RE: CBD Oil for anxiety and more - Glow - 05-16-2019, 02:20 PM
RE: CBD Oil for anxiety and more - Merrick - 05-16-2019, 03:29 PM
RE: CBD Oil for anxiety and more - Merrick - 05-24-2019, 12:43 AM
RE: CBD Oil for anxiety and more - Merrick - 05-25-2019, 06:17 AM
RE: CBD Oil for anxiety and more - Merrick - 06-02-2019, 12:50 AM
RE: CBD Oil for anxiety and more - Relax - 06-02-2019, 04:09 AM
RE: CBD Oil for anxiety and more - Merrick - 06-02-2019, 12:03 PM



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