01-20-2013, 09:05 PM
US Scientists Find That Chemotherapy Boosts Cancer Growth
Quote:The scientists found that healthy cells damaged by chemotherapy secreted more of a protein called WNT16B which boosts cancer cell survival.
“The increase in WNT16B was completely unexpected,” study co-author Peter Nelson of the Fred Hutchinson Cancer Research Center in Seattle told AFP.
The protein was taken up by tumour cells neighbouring the damaged cells.
“WNT16B, when secreted, would interact with nearby tumour cells and cause them to grow, invade, and importantly, resist subsequent therapy,” said Nelson.
In cancer treatment, tumours often respond well initially, followed by rapid regrowth and then resistance to further chemotherapy.
Rates of tumour cell reproduction have been shown to accelerate between treatments.
“Our results indicate that damage responses in benign cells… may directly contribute to enhanced tumour growth kinetics,” wrote the team.